Yes, you can use the --sponsorblock-mark parameter to add chapter marks around the segments and the --sponsorblock-remove parameter to cut the segments out of the video. I would suggest adding them to the config file for yt-dlp so you don’t have to add the parameters and all of the categories to the command every time.

Mpv doesn’t use the download function of yt-dlp, so those options won’t work with mpv. You have to install the script for that.